Article

Ultraviolet light-induced collagen degradation inhibits melanoma invasion

2021-01-28

Abstract excerpt

Ultraviolet radiation (UVR) increases the incidence of cutaneous melanoma 1–4 . The ageing, sun-exposed dermis accumulates UVR damage 5 , and older patients develop more melanomas at UVR-exposed sites 4,6,7 . As fibroblasts are functionally heterogeneous and play key roles in the stromal contribution to cancer 8,9 , we asked whether UVR modifies dermal fibroblast function. Here we confirmed the expression of c...

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Literature Corpus work: bcf3325c-c361-5c48-9890-910e3fcbb7a8
DOI: 10.1101/2021.01.27.428482

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