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Article

TGFβ Signaling in Photoaging and UV-Induced Skin Cancer.

The Journal of investigative dermatology - 1 Apr 2021

Ke Yao, Wang Xiao-Jing

Abstract excerpt

UVR is a major etiology for premature skin aging that leads to photoaging and UV-induced skin cancers. In the skin, TGFβ signaling is a growth inhibitor for keratinocytes and a profibrotic factor in the dermis. It exerts context-dependent effects on tumor progression. Chronic UV exposure likely causes TGFβ1/SMAD3 signaling activation and contributes to metalloproteinase-induced collagen degradation and...

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Source

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Identifiers

PMID: 33358021
DOI: 10.1016/j.jid.2020.11.007
PMCID: PMC7987776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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