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Article

Reduced expression of IL-18 is a marker of ultraviolet radiation-induced melanomas.

International journal of cancer - 1 Jul 2008

Hacker Elke, Muller Konrad, Whiteman David C, Pavey Sandra, Hayward Nicholas, Walker Graeme

Abstract excerpt

We previously showed that mice carrying an activated Cdk4 mutation together with melanocyte-specific mutant Hras (Cdk4(R24C/R24C)/TPras) develop melanoma spontaneously, but penetrance is increased and age of onset reduced after neonatal ultraviolet radiation (UVR) exposure. UVR-treated mice were more likely to develop multiple primary lesions, and these melanomas more often expressed Trp53, and less often...

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Identifiers

PMID: 18386818
DOI: 10.1002/ijc.23389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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