Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Melanoma–Keratinocyte Crosstalk Participates in Melanoma Progression with Mechanisms Partially Overlapping with Those of Cancer-Associated Fibroblasts

15 Aug 2025

Abstract excerpt

The Tumour Microenvironment (TME) is pivotal for melanoma progression and contributes to therapy resistance. While dermal cell involvement is well established, the role of epidermal cells remains less defined. To explore the contribution of Normal Human Keratinocytes (NHKs) to melanoma biology, we investigated the modification of gene and protein expression of NHKs exposed to melanoma-conditioned medium or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cellular Mechanics and Interactions
Share to Melanoma and MAPK Pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40869222
DOI: 10.3390/ijms26167901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Melanoma–Keratinocyte Crosstalk Participates in Melanoma Progression with Mechanisms Partially Overlapping with Those of Cancer-Associated FibroblastsPMID 40869222Read ↗

Influence of Tumor Microenvironment and Fibroblast Population Plasticity on Melanoma Growth, Therapy Resistance and ImmunoescapeSemantic proximity Read ↗

Profiling Cancer-Associated Fibroblasts in MelanomaSemantic proximity Read ↗

The Role of Fibroblasts in Melanoma Development: From Tumor Microenvironment Remodeling to Pre-Metastatic Niche FormationSemantic proximity Read ↗

Melanoma cells with diverse invasive potential differentially induce the activation of normal human fibroblastsSemantic proximity Read ↗

Bidirectional cross talk between patient‐derived melanoma and cancer‐associated fibroblasts promotes invasion and proliferationSemantic proximity Read ↗

Development of a Stromal Microenvironment Experimental Model Containing Proto-Myofibroblast Like Cells and Analysis of Its Crosstalk with Melanoma Cells: A New Tool to Potentiate and Stabilize Tumor Suppressor Phenotype of Dermal Myofibroblasts.Semantic proximity Read ↗

Heterotypic signaling between dermal fibroblasts and melanoma cells induces phenotypic plasticity and proteome rearrangement in malignant cells.Semantic proximity Read ↗

Melanoma and the tumor microenvironment.Semantic proximity Read ↗

Gene Expression Profiling Reveals Cross-talk between Melanoma and Fibroblasts: Implications for Host-Tumor Interactions in MetastasisSemantic proximity Read ↗

Microenvironment and tumor progression of melanoma: New therapeutic prospectivesSemantic proximity Read ↗

Insights into the Transforming Growth Factor-β Signaling Pathway in Cutaneous MelanomaSemantic proximity Read ↗

BRAF(V600E) melanoma cells secrete factors that activate stromal fibroblasts and enhance tumourigenicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.