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Article

Loss of XRCC 1 confers a metastatic phenotype to melanoma cells and is associated with poor survival in patients with melanoma

11 Jan 2014

Abstract excerpt

Ultraviolet (UV) radiation-induced DNA damage and genomic instability is one of the leading causes for melanoma. X-ray repair cross-complementary protein 1, XRCC1, plays a critically important role in base excision repair pathway. This study was therefore performed to analyze the correlation between XRCC1 expression, melanoma progression, and patient survival. Using a tissue microarray with a total of 119...

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Share to Cutaneous Melanoma Detection and Management
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PMID: 24410901
DOI: 10.1111/pcmr.12212

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