Article
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling.
The Journal of biological chemistry - 6 Aug 2004
Huntington Jonathan T, Shields Janiel M, Der Channing J, Wyatt Colby A, Benbow Ulrike, Slingluff Craig L, Brinckerhoff Constance E
Abstract excerpt
Melanoma progresses as a multistep process where the thickness of the lesion and depth of tumor invasion are the best prognostic indicators of clinical outcome. Degradation of the interstitial collagens in the extracellular matrix is an integral component of tumor invasion and metastasis, and much of this degradation is mediated by collagenase-1 (MMP-1), a member of the matrix metalloproteinase (MMP) family....
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