Article

A human <i>ex vivo</i> model of radiation-induced skin injury reveals p53-driven DNA damage signaling and recapitulates a TGFβ fibrotic response

2025-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Radiation-induced skin injury is a poorly understood complication affecting cancer patients who undergo radiotherapy, with no current therapies able to prevent or halt its progression to debilitating radiation-induced skin fibrosis (RISF). Addressing the need for clinically relevant human models, this study developed and characterized a human ex vivo skin model that recapitulates the temporal m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4e0c6519-f92c-5fec-a97f-72816f7ca045
DOI: 10.1101/2025.06.04.657901

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A human <i>ex vivo</i> model of radiation-induced skin injury reveals p53-driven DNA damage signaling and recapitulates a TGFβ fibrotic responseDOI 10.1101/2025.06.04.657901Read

Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivorsSemantic proximity Read

Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosisSemantic proximity Read

Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivorsSemantic proximity Read

Mechanisms of radiation-induced skin injury and implications for future clinical trialsSemantic proximity Read

Molecular biological mechanisms of radiotherapy-induced skin injury occurrence and treatmentSemantic proximity Read

TGFβ Signaling in Photoaging and UV-Induced Skin Cancer.Semantic proximity Read

Identification of Differential Gene Expression Patterns after Acute Exposure to High and Low Doses of Low-LET Ionizing Radiation in a Reconstituted Human Skin TissueSemantic proximity Read

Comparison of the biological effects of various radiation therapy for keloid by single-cell RNA sequencing reveals IRF1 as a novel target in keloid therapySemantic proximity Read

Predicting neutron radiation exposure characteristics from an <i>in vitro</i> human skin model using RNA-seqSemantic proximity Read

Genomic characterization of a three-dimensional skin model following exposure to ionizing radiationSemantic proximity Read

Localized FLASH Radiotherapy Reduces Long-Term Skin and Muscle Damage While Preserving Systemic HomeostasisSemantic proximity Read

Portrait of inflammatory response to ionizing radiation treatmentSemantic proximity Read