Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant collagen COL11A1 enhances cancerous invasion.

Oncogene - 1 Nov 2021

Lee Carolyn S, Siprashvili Zurab, Mah Angela, Bencomo Tomas, Elcavage Lara E, Che Yonglu, Shenoy Rajani M, Aasi Sumaira Z, Khavari Paul A

Abstract excerpt

Collagens are the most abundant proteins in the body and comprise the basement membranes and stroma through which cancerous invasion occurs; however, a pro-neoplastic function for mutant collagens is undefined. Here we identify COL11A1 mutations in 66 of 100 cutaneous squamous cell carcinomas (cSCCs), the second most common U.S. cancer, concentrated in a triple helical region known to produce trans-dominant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Collagen Type XI

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exome Sequencing

Share to Integrin beta1

Share to Neoplasm Invasiveness

Share to Neoplasm Transplantation

Share to Protein Structure, Secondary

Share to Skin Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 34584216
DOI: 10.1038/s41388-021-02013-y
PMCID: PMC8566234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant collagen COL11A1 enhances cancerous invasion.PMID 34584216Read ↗

Oncogenic mechanisms of COL10A1 in cancer and clinical challenges (Review)Semantic proximity Read ↗

Modulating Collagen I Expression in Fibroblasts by CRISPR-Cas9 Base Editing of the Collagen 1A1 PromoterSemantic proximity Read ↗

Mutation of the Collagen Type 1α Gene in Human Fibrosarcoma Cells Using the CRISPR/Cas9 System.Semantic proximity Read ↗

Fibroblast-Derived Dermal Matrix Drives Development of Aggressive Cutaneous Squamous Cell Carcinoma in Patients with Recessive Dystrophic Epidermolysis BullosaSemantic proximity Read ↗

Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencingSemantic proximity Read ↗

Identification of tissue damage, extracellular matrix remodeling and bacterial challenge as common mechanisms associated with high-risk cutaneous squamous cell carcinomas.Semantic proximity Read ↗

Tumor collagens predict genetic features and patient outcomesSemantic proximity Read ↗

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biologySemantic proximity Read ↗

Type VII collagen is required for Ras-driven human epidermal tumorigenesis.Semantic proximity Read ↗

Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma CellsSemantic proximity Read ↗

Collagens in Cancer: Structural Regulators and Guardians of Cancer ProgressionSemantic proximity Read ↗

Exploring the Differential Expression and Prognostic Significance of the COL11A1 Gene in Human Colorectal Carcinoma: An Integrated Bioinformatics ApproachSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.