Article

Thousands of novel unannotated proteins expand the MHC I immunopeptidome in cancer

2020-02-13

Abstract excerpt

Tumor epitopes – peptides that are presented on surface-bound MHC I proteins - provide targets for cancer immunotherapy and have been identified extensively in the annotated protein-coding regions of the genome. Motivated by the recent discovery of translated novel unannotated open reading frames (nuORFs) using ribosome profiling (Ribo-seq), we hypothesized that cancer-associated processes could generate nuORFs th...

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Literature Corpus work: 89a238f0-6005-508c-ad89-744427eb94cd
DOI: 10.1101/2020.02.12.945840

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