Article

hsegHMM: Hidden Markov Model-based Allele-specific Copy Number Alteration Analysis Accounting for Hypersegmentation

2018-09-06

Abstract excerpt

<h4>Background:</h4> Somatic copy number alternation (SCNA) is a common feature of the cancer genome and is associated with cancer etiology and prognosis. The allele-specific SCNA analysis of a tumor sample aims to identify the allele-specific copy numbers of both alleles, adjusting for the ploidy and the tumor purity. Next generation sequencing platforms produce abundant read counts at the base-pair resolution a...

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Literature Corpus work: 3ad64a9e-8fb6-5605-80dd-7ff4171cfd82
DOI: 10.1101/410845

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