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Human blastoids model blastocyst development and implantation

2 Dec 2021

Abstract excerpt

Abstract One week after fertilization, human embryos implant into the uterus. This event requires the embryo to form a blastocyst consisting of a sphere encircling a cavity lodging the embryo proper. Stem cells can form a blastocyst model that we called a blastoid 1 . Here we show that naive human pluripotent stem cells cultured in PXGL medium 2 and triply inhibited for the Hippo, TGF-β and ERK pathways...

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PMID: 34856602
DOI: 10.1038/s41586-021-04267-8

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