Article

SEACells: Inference of transcriptional and epigenomic cellular states from single-cell genomics data

2022-04-03

Abstract excerpt

<h4>ABSTRACT</h4> Metacells are cell groupings derived from single-cell sequencing data that represent highly granular, distinct cell states. Here, we present single-cell aggregation of cell-states (SEACells), an algorithm for identifying metacells; overcoming the sparsity of single-cell data, while retaining heterogeneity obscured by traditional cell clustering. SEACells outperforms existing algorithms in identi...

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Literature Corpus work: fb6d959b-4cbe-5572-b1a1-bf33cfdeb007
DOI: 10.1101/2022.04.02.486748

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