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Article

iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility.

The Journal of investigative dermatology - 1 Apr 2021

Chao-Chu Jennifer, Murtough Stephen, Zaman Najwa, Pennington Daniel J, Blaydon Diana C, Kelsell David P

Abstract excerpt

The palmoplantar epidermis is a specialized area of the skin that undergoes high levels of mechanical stress. The palmoplantar keratinization and esophageal cancer syndrome, tylosis with esophageal cancer, is linked to mutations in RHBDF2 encoding the proteolytically inactive rhomboid protein, iRhom2. Subsequently, iRhom2 was found to affect palmoplantar thickening to modulate the stress keratin response and to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33080304
DOI: 10.1016/j.jid.2020.09.010
PMCID: PMC7568177

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