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Article

Linear ubiquitination prevents inflammation and regulates immune signalling.

Nature - 31 Mar 2011

Gerlach Björn, Cordier Stefanie M, Schmukle Anna C, Emmerich Christoph H, Rieser Eva, Haas Tobias L, Webb Andrew I, Rickard James A, Anderton Holly, Wong Wendy W-L, Nachbur Ueli, Gangoda Lahiru, Warnken Uwe, Purcell Anthony W, Silke John, Walczak Henning

Abstract excerpt

Members of the tumour necrosis factor (TNF) receptor superfamily have important functions in immunity and inflammation. Recently linear ubiquitin chains assembled by a complex containing HOIL-1 and HOIP (also known as RBCK1 and RNF31, respectively) were implicated in TNF signalling, yet their relevance in vivo remained uncertain. Here we identify SHARPIN as a third component of the linear ubiquitin chain assembly...

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Source

Identifiers

PMID: 21455173
DOI: 10.1038/nature09816

Genes

TNF
SHARPIN
RBCK1
RIPK1
RNF31

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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