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Article

A Nerve-Fibroblast Axis in Mammalian Lung Fibrosis

2024-09-09

Abstract excerpt

<h4>ABSTRACT</h4> Fibrosis contributes to incurable pathologies in vital organs including the lung. Myofibroblasts are fibrogenic effector cells that accumulate via incompletely understood mechanisms. We discovered that α1-adrenoreceptor expressing myofibroblasts receive sympathetic nerve-derived noradrenergic inputs in fibrotic mouse and human lungs. We combined optical clearing, whole lung imaging, cell-specifi...

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Literature Corpus work
bcced7e8-4bc3-5eb6-99a5-b111577e09f3
DOI
10.1101/2024.09.09.611003
Open publication

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A Nerve-Fibroblast Axis in Mammalian Lung FibrosisDOI 10.1101/2024.09.09.611003
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