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Article

Targeting the epithelium in pulmonary fibrosis.

European respiratory review : an official journal of the European Respiratory Society - 1 Jan 2026

Lizé Muriel, Mayr Christoph H, Bleck Marina, Wollin Lutz, Wohnhaas Christian T, Shalashova Irina, Olbrich Heiko, Heilker Ralf, Engler Anna, Bammert Marie-Therese, Schlüter Holger, Geillinger-Kästle Kerstin, Soetopo Devona, Klee Stephan, Wolf Felix, Gokey Jason J, Stahl Heiko, Klimowicz Alexander C, McCall A Scott, Kropski Jonathan A, Blackwell Timothy S, Thomas Matthew J

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is characterised by progressive scarring primarily of the distal regions of the lung in a distinctive histological pattern. Consequently, drug discovery has focused on the activity of scar-forming fibroblasts, with some success shown by the pharmaceutical agents nintedanib and pirfenidone, and more recently nerandomilast. Yet an unmet medical need remains, pointing toward...

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Identifiers

PMID: 41881452
DOI: 10.1183/16000617.0225-2025
PMCID: PMC13014285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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