Article

Parkinson’s Disease-Linked Kir4.2 Mutation R28C Leads to Loss of Ion Channel Function

2024-05-07

Abstract excerpt

Parkinson’s disease (PD) is a complex, progressive neurodegenerative disorder driven by multiple pathogenetic factors, including oxidative stress, mitochondria dysfunction, neuroinflammation, and ion imbalance. Recent evidence highlights the significant role of potassium channels in the pathophysiology of PD. We recently identified a PD-linked genetic mutation in the KCNJ15 gene ( KCNJ15 p.R28C ), encoding the...

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Literature Corpus work: 80cd5b48-1032-5967-a250-0380405500c9
DOI: 10.1101/2024.05.05.592599

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