Article
Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease.
Neurobiology of disease - 1 Oct 2014
Dave Kuldip D, De Silva Shehan, Sheth Niketa P, Ramboz Sylvie, Beck Melissa J, Quang Changyu, Switzer Robert C, Ahmad Syed O, Sunkin Susan M, Walker Dan, Cui Xiaoxia, Fisher Daniel A, McCoy Aaron M, Gamber Kevin, Ding Xiaodong, Goldberg Matthew S, Benkovic Stanley A, Haupt Meredith, Baptista Marco A S, Fiske Brian K, Sherer Todd B, Frasier Mark A
Abstract excerpt
Recessively inherited loss-of-function mutations in the PTEN-induced putative kinase 1(Pink1), DJ-1 (Park7) and Parkin (Park2) genes are linked to familial cases of early-onset Parkinson's disease (PD). As part of its strategy to provide more tools for the research community, The Michael J. Fox Foundation for Parkinson's Research (MJFF) funded the generation of novel rat models with targeted disruption ofPink1,...
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