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Article

Parkinson's disease-linked Kir4.2 mutation R28C leads to loss of ion channel function.

The Journal of physiology - 1 Jun 2025

Chen Xiaoyi, Finol-Urdaneta Rocio K, Chen Mo, Sykes Alex M, Gao Bingmiao, Iqbal Jamila, Adams David J, Mellick George D, Ma Linlin

Abstract excerpt

Parkinson's disease (PD) is a complex, progressive neurodegenerative disorder driven by multiple pathogenetic factors, including oxidative stress, mitochondria dysfunction, neuroinflammation and ion imbalance. Recent evidence highlights the significant role of potassium channels in the pathophysiology of PD. We recently identified a PD-linked genetic mutation in the KCNJ15 gene (KCNJ15p.R28C), encoding the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40566643
DOI: 10.1113/JP287046
PMCID: PMC12206441

Genes

KCNJ15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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