Article

Adult-Onset Deletion of <i>ATP13A2</i> in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities

2024-01-26

Abstract excerpt

Although most cases of Parkinson’s disease (PD) are sporadic, mutations in over 20 genes are known to cause heritable forms of PD. A surprising number of familial PD-linked genes and PD risk genes are involved in intracellular trafficking and protein degradation. Recessive loss-of-function mutations in ATP13A2 , a lysosomal transmembrane P5 B -type ATPase and polyamine exporter, can cause early-onset familial PD...

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Literature Corpus work: 261f40ee-67e7-59f9-9cc9-6877fa5f0b7e
DOI: 10.1101/2024.01.25.577280

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