Article

COUP-TFII regulates early bipotential gonad signaling and commitment to ovarian progenitors

2023-08-12

Abstract excerpt

The absence of expression of the Y-chromosome linked testis-determining gene SRY in early supporting gonadal cells (ESGC) of bipotential gonads leads to ovarian development. However, genetic variants in NR2F2 /COUP-TFII represent a novel cause of SRY -negative 46,XX testicular/ovotesticular differences of sex development (T/OT-DSD). Thus, we hy-pothesized that COUP-TFII is part of the ovarian developmental netw...

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Literature Corpus work: bc98f508-363d-5282-88ba-9255e1faa775
DOI: 10.1101/2023.08.09.552582

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