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Article

Evidence for NR2F2/COUP-TFII involvement in human testis development.

Scientific reports - 1 Aug 2024

Wankanit Somboon, Zidoune Housna, Bignon-Topalovic Joëlle, Schlick Laurène, Houzelstein Denis, Fusée Leila, Boukri Asma, Nouri Nassim, McElreavey Ken, Bashamboo Anu, Elzaiat Maëva

Abstract excerpt

NR2F2 encodes COUP-TFII, an orphan nuclear receptor required for the development of the steroidogenic lineages of the murine fetal testes and ovaries. Pathogenic variants in human NR2F2 are associated with testis formation in 46,XX individuals, however, the function of COUP-TFII in the human testis is unknown. We report a de novo heterozygous variant in NR2F2 (c.737G > A, p.Arg246His) in a 46,XY...

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Identifiers

PMID: 39090159
DOI: 10.1038/s41598-024-68860-3
PMCID: PMC11294483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence for NR2F2/COUP-TFII involvement in human testis development.PMID 39090159Read ↗

Evidence for <i>NR2F2</i> /COUP-TFII involvement in human testis developmentSemantic proximity Read ↗

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