Article
Steroidogenic factor 1 (NR5A1) induces multiple transcriptional changes during differentiation of human gonadal-like cells.
Differentiation; research in biological diversity - 1 Jan 2000
Sepponen Kirsi, Lundin Karolina, Yohannes Dawit A, Vuoristo Sanna, Balboa Diego, Poutanen Matti, Ohlsson Claes, Hustad Steinar, Bifulco Ersilia, Paloviita Pauliina, Otonkoski Timo, Ritvos Olli, Sainio Kirsi, Tapanainen Juha S, Tuuri Timo
Abstract excerpt
Nuclear receptor subfamily 5 group A member 1 (NR5A1) encodes steroidogenic factor 1 (SF1), a key regulatory factor that determines gonadal development and coordinates endocrine functions. Here, we have established a stem cell-based model of human gonadal development and applied it to evaluate the effects of NR5A1 during the transition from bipotential gonad to testicular cells. We combined directed...
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