Article

Evidence for <i>NR2F2</i> /COUP-TFII involvement in human testis development

2024-01-06

Abstract excerpt

NR2F2 encodes COUP-TFII, an orphan nuclear receptor involved in mammalian gonadogenesis. COUP-TFII is expressed in the interstitial/stromal compartment of both fetal testes and ovaries, where it is required for developing steroidogenic lineages. Pathogenic variants in human NR2F2 are linked to testis formation in 46,XX individuals (46,XX d isorders of s ex d evelopment, 46,XX DSD). Such findings propose a regu...

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Literature Corpus work: 62ddfb75-dacf-5403-aa84-ffaa408af248
DOI: 10.1101/2024.01.05.574424

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