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Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

19 Jan 2023

Abstract excerpt

An in vitro model of human ovarian follicles would greatly benefit the study of female reproduction. Ovarian development requires the combination of germ cells and several types of somatic cells. Among these, granulosa cells play a key role in follicle formation and support for oogenesis. Whereas efficient protocols exist for generating human primordial germ cell-like cells (hPGCLCs) from human induced...

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PMID: 36803359
DOI: 10.7554/elife.83291

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