Article

PI3K inhibitor-free differentiation and maturation of human iPSC-derived arterial- and venous-like endothelial cells

2026-01-12

Abstract excerpt

Congenital vascular malformations are commonly caused by aberrant, genetic activation of class I phosphoinositide 3-kinase (PI3K) signalling. Advances in mechanistic understanding and therapeutic targeting of these disorders will be accelerated by high-fidelity, human disease models. Building on a previously optimised differentiation strategy, we present a validated workflow for PI3K inhibitor-free generation of a...

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Literature Corpus work: b6620f68-fe27-5778-b105-c1e4d3affea1
DOI: 10.64898/2026.01.10.698801

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