Article

Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic α-synuclein

2021-05-01

Abstract excerpt

Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) forms a complex with Lag3 that facilitates the binding, internalization, transmission, and toxicity of pathologic α-syn. Deletion of both Aplp1 and Lag3 eliminates the loss of dopaminergic neurons and the accompanying behaviora...

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Literature Corpus work: 9acb4483-3119-5c3e-a395-1b26732bd085
DOI: 10.1101/2021.05.01.442157

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