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Article

PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport.

Acta neuropathologica - 16 Feb 2024

Tziortzouda Paraskevi, Steyaert Jolien, Scheveneels Wendy, Sicart Adria, Stoklund Dittlau Katarina, Barbosa Correia Adriana Margarida, Burg Thibaut, Pal Arun, Hermann Andreas, Van Damme Philip, Moens Thomas G, Van Den Bosch Ludo

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which currently lacks effective treatments. Mutations in the RNA-binding protein FUS are a common cause of familial ALS, accounting for around 4% of the cases. Understanding the mechanisms by which mutant FUS becomes toxic to neurons can provide insight into the pathogenesis of both familial and sporadic ALS. We have previously observed that...

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Identifiers

PMID: 38363426
DOI: 10.1007/s00401-024-02689-y
PMCID: PMC10873455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport.PMID 38363426Read ↗

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