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Hippocampal mitophagy alterations in MAPT-associated frontotemporal dementia with parkinsonism

24 Feb 2025

Abstract excerpt

The enzyme pair PINK1 and PRKN together orchestrates a cytoprotective mitophagy pathway that selectively tags damaged mitochondria with phospho-serine 65 ubiquitin (pS65-Ub) and directs them for autophagic-lysosomal degradation (mitophagy). We previously demonstrated a significant accumulation of pS65-Ub signals in autopsy brains of sporadic Lewy body disease and Alzheimer's disease cases, which strongly...

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PMID: 39994734
DOI: 10.1186/s40478-025-01955-8

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