Article

Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation

2025-01-04

Abstract excerpt

Lymphocyte activation gene 3 (LAG3) is a key receptor involved in the propagation of pathological proteins in Parkinson’s disease (PD). This study investigates the role of neuronal LAG3 in mediating the binding, uptake, and propagation of α-synuclein (αSyn) preformed fibrils (PFFs). Using neuronal LAG3 conditional knockout mice and human induced pluripotent stem cells-derived dopaminergic (DA) neurons, we demonstr...

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Literature Corpus work: 7b6c776a-495e-5731-af22-b5846d9994c2
DOI: 10.1101/2025.01.03.631221

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