Article

PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport

2023-08-29

Abstract excerpt

ALS is a fatal neurodegenerative disease which currently lacks effective treatments. Mutations in the RNA-binding protein FUS are a common cause of familial ALS, accounting for around 4% of fALS cases. Studying the mechanisms by which mutant FUS is toxic to neurons may provide insight into the pathogenesis of both familial and sporadic forms of ALS. Here we identify Protein Phosphatase 2A (PP2A) and Glycogen Synth...

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Literature Corpus work: 1baedc77-1f95-5137-9db5-699fcfa4d0cf
DOI: 10.1101/2023.08.28.555106

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