Article

RNA m6A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression

2023-03-15

Abstract excerpt

Emergency granulopoiesis and neutrophil mobilization that can be triggered by granulocyte colony-stimulating factor (G-CSF) through its receptor G-CSFR are essential for antibacterial innate defense. Yet the epigenetic modifiers crucial for intrinsically regulating G-CSFR expression and neutrophil innate response against bacterial infection remain largely unclear. N 6 -methyladenosine (m 6 A) RNA modification and...

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Literature Corpus work: ac980c3f-9f3b-5a8a-b2ad-4859fa6b09fd
DOI: 10.21203/rs.3.rs-2676926/v1

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