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Monocyte Subsets with High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated by IRF8

2020-06-03

Abstract excerpt

<h4>SUMMARY</h4> Osteoclasts (OCs) are bone resorbing cells formed by the serial fusion of monocytes. In mice and humans, three distinct subsets of monocytes exist; however, it is unclear if all of them exhibit osteoclastogenic potential. Here we show that in wild-type mice, Ly6C hi and Ly6C int monocytes are the primary source of OC formation when compared to Ly6C − monocytes. Their osteoclastogenic potential...

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Literature Corpus work
51545cf8-14f6-5a0a-befd-8639ec472cac
DOI
10.1101/2020.06.02.126284
Open publication

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Monocyte Subsets with High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated by IRF8DOI 10.1101/2020.06.02.126284
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