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Article

A RUNX-CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes.

Nature immunology - 1 Mar 2021

Murakami Koichi, Sasaki Haruka, Nishiyama Akira, Kurotaki Daisuke, Kawase Wataru, Ban Tatsuma, Nakabayashi Jun, Kanzaki Satoko, Sekita Yoichi, Nakajima Hideaki, Ozato Keiko, Kimura Tohru, Tamura Tomohiko

Abstract excerpt

The transcription factor IRF8 is essential for the development of monocytes and dendritic cells (DCs), whereas it inhibits neutrophilic differentiation. It is unclear how Irf8 expression is regulated and how this single transcription factor supports the generation of both monocytes and DCs. Here, we identified a RUNX-CBFβ-driven enhancer 56 kb downstream of the Irf8 transcription start site. Deletion of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33603226
DOI: 10.1038/s41590-021-00871-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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