Article
An atlas of genetic effects on cellular composition of the tumor microenvironment.
Nature immunology - 1 Oct 2024
Cai Yimin, Lu Zequn, Chen Can, Zhu Ying, Chen Zhirui, Wu Zuyou, Peng Jingyi, Zhu Xuanyu, Liu Ziying, Li Bin, Zhang Ming, Huang Jinyu, Li Yanmin, Liu Yizhuo, Ma Qianying, He Chunyi, Chen Shuoni, Tian Wen, Fan Linyun, Ning Caibo, Geng Hui, Xu Bin, Li Haijie, Zhu Xu, Fang Jun, Wang Xiaoyang, Zhang Shaokai, Jin Meng, Huang Chaoqun, Yang Xiaojun, Tian Jianbo, Miao Xiaoping
Abstract excerpt
Deciphering the composition of the tumor microenvironment (TME) is critical for understanding tumorigenesis and to design immunotherapies. In the present study, we mapped genetic effects on cell-type proportions using single-cell and bulk RNA sequencing data, identifying 3,494 immunity quantitative trait loci (immunQTLs) across 23 cancer types from The Cancer Genome Atlas. Functional annotation revealed...
Topics
- Humans
- Tumor Microenvironment
- Quantitative Trait Loci
- Genome-Wide Association Study
- Colorectal Neoplasms
- Polymorphism, Single Nucleotide
- Chemokine CCL2
- Receptors, CCR2