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Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade.

Cell reports - 3 Jan 2017

Charoentong Pornpimol, Finotello Francesca, Angelova Mihaela, Mayer Clemens, Efremova Mirjana, Rieder Dietmar, Hackl Hubert, Trajanoski Zlatko

Abstract excerpt

The Cancer Genome Atlas revealed the genomic landscapes of human cancers. In parallel, immunotherapy is transforming the treatment of advanced cancers. Unfortunately, the majority of patients do not respond to immunotherapy, making the identification of predictive markers and the mechanisms of resistance an area of intense research. To increase our understanding of tumor-immune cell interactions, we characterized...

Topics

Antigens, Neoplasm
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
CTLA-4 Antigen
Cell Cycle Checkpoints
Genomics
Genotype
Humans
Immunophenotyping
Immunotherapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Machine Learning

Mutation

Neoplasms

Prognosis

Programmed Cell Death 1 Receptor

Source

Identifiers

PMID: 28052254
DOI: 10.1016/j.celrep.2016.12.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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