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Article

Genomic instability in breast cancer: pathogenesis and clinical implications.

Molecular oncology - 1 Jun 2010

Kwei Kevin A, Kung Yvonne, Salari Keyan, Holcomb Ilona N, Pollack Jonathan R

Abstract excerpt

Breast cancer is a heterogeneous disease, appreciable by molecular markers, gene-expression profiles, and most recently, patterns of genomic alteration. In particular, genomic profiling has revealed three distinct patterns of DNA copy-number alteration: a "simple" type with few gains or losses of whole chromosome arms, an "amplifier" type with focal high-level DNA amplifications, and a "complex" type marked by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20434415
DOI: 10.1016/j.molonc.2010.04.001
PMCID: PMC2904860

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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