Article

Defining relative mutational difficulty to understand cancer formation and prevention

2019-10-01

Abstract excerpt

<h4>Summary</h4> Most mutations in human cancer are low-frequency missense mutations, whose functional status remains hard to predict. Here we show that depending on the type of nucleotide change and the surrounding sequences, the tendency to generate each type of nucleotide mutations varies greatly, even by several hundred folds. Therefore, a cancer-promoting mutation may appear only in a small number of cancer...

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Literature Corpus work: bc60b5ee-6141-562f-9665-5519a128bd3b
DOI: 10.1101/789313

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