Article

Multistep metabolic engineering of <i>Bacillus licheniformis</i> to improve pulcherriminic acid production

2019-10-02

Abstract excerpt

Pulcherriminic acid, a cyclodipeptide, possesses the excellent antibacterial activities by chelating iron ions from environment, however, the low yield has hindered its application. In this study, high-level production of pulcherriminic acid was achieved by the multistep metabolic engineering of Bacillus licheniformis DWc9n*. Firstly, leucine (Leu) supply was increased by overexpressing the genes ilvBHC-leuABCD...

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Literature Corpus work: bc49218a-d9d8-529b-bfed-30528eed93c6
DOI: 10.1101/790691

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