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Pulcherriminic acid biosynthesis and Transport: Insights from a heterologous system in <i>Saccharomyces cerevisiae</i>

2025-03-18

Abstract excerpt

Pulcherriminic acid is an iron chelator produced by some Kluyveromyces and Metschnikowia yeasts. Its biosynthesis is encoded by the four–gene PUL cluster, where PUL1 and PUL2 are the biosynthetic enzymes, PUL3 mediates the uptake of iron–bound pulcherrimin, and PUL4 is a putative regulator. Pulcherriminic acid holds antifungal potential, as the growth of organisms unable to uptake pulcherrimin is inhibited...

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Literature Corpus work
6c0d4189-5a92-5835-85ef-5416ec117498
DOI
10.1101/2025.03.18.643849
Open publication

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