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Reassembly of the Biosynthetic Gene Cluster Enables High Epothilone Yield in Engineered Schlegelella brevitalea

30 Jun 2020

Abstract excerpt

Epothilones, as a new class of microtubule-stabilizing anticancer drugs, exhibit strong bioactivity against taxane-resistant cells and show clinical activity for the treatment of advanced breast cancer. Additionally, they also show great potential for a central nervous system injury and Alzheimer’s disease. However, due to the long fermentation period of the original producer and challenges of genetic engineering...

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PMID: 32603592
DOI: 10.1021/acssynbio.0c00100

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