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Melanin Biosynthesis and Omics: Homogentisate Pathway Dysfunction Drives Pyomelanin Production in Mutant Bacillus thuringiensis var. israelensis MB-24.

Omics : a journal of integrative biology - 1 Oct 2025

Bharadwaj Nikhil, Nenavath Jyothi, Subramanian Muthukumaravel, Upadhyay Shubham S, Prasad Thottethodi Subrahmanya Keshava, Hoti Sugeerappa L

Abstract excerpt

Melanin is a complex biopolymer with antioxidative, UV-protective, and antimicrobial properties. Melanin is also of interest for bioengineering applications in healthcare. Its production has been frequently observed in several bacteria and higher organisms under specific culture conditions through genetic engineering and chemical mutagenesis. Interestingly, l-DOPA, a precursor to the neurotransmitter dopamine and...

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PMID: 40991423
DOI: 10.1177/15578100251380105

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