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Improved milbemycin production by engineering two Cytochromes P450 in Streptomyces bingchenggensis.

Applied microbiology and biotechnology - 1 Apr 2020

Wang Haiyan, Cheng Xu, Liu Yuqing, Li Shanshan, Zhang Yanyan, Wang Xiangjing, Xiang Wensheng

Abstract excerpt

Milbemycins and their semisynthetic derivatives are recognized as effective and eco-friendly pesticides, whereas the high price limits their widespread applications in agriculture. One of the pivotal questions is the accumulation of milbemycin-like by-products, which not only reduces the yield of the target products milbemycin A3/A4, but also brings difficulty to the purification. With other analogous by-products...

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PMID: 32043186
DOI: 10.1007/s00253-020-10410-8

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