Article

Taliglucerase Alfa Modulates Aβ Load and Autophagy-Related Pathways in Mouse Hippocampal Neurons Exposed to oAβ1-42

2025-08-04

Abstract excerpt

<title>Abstract</title> <p>Intraneuronal amyloid-beta (Aβ) accumulation and autophagic dysfunction are key pathological features of Alzheimer's disease (AD). Mutations in <italic>GBA1</italic>, which encodes the lysosomal enzyme β-glucocerebrosidase (GCase), are linked to several neurodegenerative disorders, but the role of GCase in AD is underexplored. We hypothesized that taliglucerase alfa (TAL), a recombinant...

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Literature Corpus work: bc0b1d10-1340-5afc-aa75-9bc5d55d0b52
DOI: 10.21203/rs.3.rs-7094261/v1

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