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Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu

9 Feb 2015

Abstract excerpt

Autophagy is a housekeeping process responsible for the bulk degradation of misfolded protein aggregates and damaged organelles through the lysosomal machinery. Given its key role as a cellular quality control mechanism, autophagy is now a focus of intense scrutiny in Alzheimer's disease (AD). The hallmarks of this devastating neurodegenerative disease are the accumulation of misfolded amyloid-β (Aβ) peptide and...

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PMID: 25664381
DOI: 10.1089/dna.2014.2757

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