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Article

Lamotrigine Reduces β-Site AβPP-Cleaving Enzyme 1 Protein Levels Through Induction of Autophagy.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Wu Hao, Lu Mei-Hong, Wang Wang, Zhang Mao-Ying, Zhu Qian-Qian, Xia Yi-Yuan, Xu Ru-Xiang, Yang Yi, Chen Li-Hua, Ma Quan-Hong

Abstract excerpt

Lamotrigine (LTG), a broad-spectrum anti-epileptic drug widely used in treatment for seizures, shows potential efficacy in Alzheimer's disease (AD) therapy. Chronic LTG treatment rescues the suppressed long-term potentiation, loss of spines and cognitive deficits in AβPP/PS1 mice, known to overexpress a chimeric mouse/human mutant amyloid-β protein precursor (AβPP) and a mutant human presenilin 1 (PS1). These...

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Identifiers

PMID: 25854934
DOI: 10.3233/JAD-143162

Genes

BACE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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