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TFEB in Alzheimer's disease: From molecular mechanisms to therapeutic implications

27 Aug 2022

Abstract excerpt

Alzheimer's disease (AD), an age-dependent neurodegenerative disorder, is the most prevalent neurodegenerative disease worldwide. The primary pathological hallmarks of AD are the deposition of β-amyloid plaques and neurofibrillary tangles. Autophagy, a pathway of clearing damaged organelles, macromolecular aggregates, and long-lived proteins via lysosomal degradation, has emerged as critical for proteostasis in...

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PMID: 36031168
DOI: 10.1016/j.nbd.2022.105855

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