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Autophagy and Alzheimer’s Disease: Mechanisms and Impact Beyond the Brain

16 Jun 2025

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by neuronal loss, cognitive decline, and pathological hallmarks such as amyloid-beta (Aβ) plaques and tau neurofibrillary tangles. Recent evidence highlights autophagy as a pivotal mechanism in cellular homeostasis, mediating the clearance of misfolded proteins and damaged organelles. However, impaired autophagy contributes significantly...

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PMID: 40558538
DOI: 10.3390/cells14120911

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