Article

A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer

2024-08-26

Abstract excerpt

Although localized prostate cancer is relatively indolent, advanced prostate cancer manifests with aggressive and often lethal variants, including neuroendocrine prostate cancer (NEPC). To identify drivers of aggressive prostate cancer, we leveraged Sleeping Beauty (SB) transposon mutagenesis in a mouse model based on prostate-specific loss-of-function of Pten and Tp53 . Compared with control mice, SB mice dev...

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Identifiers and source

Literature Corpus work: bc07979e-f264-59f9-9591-b752dc92acd9
DOI: 10.1101/2024.08.24.609538

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