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Article

SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors.

Scientific reports - 29 Apr 2015

Malik Shivani, Villanova Lidia, Tanaka Shinji, Aonuma Misato, Roy Nilotpal, Berber Elisabeth, Pollack Jonathan R, Michishita-Kioi Eriko, Chua Katrin F

Abstract excerpt

Metastasis is responsible for over 90% of cancer-associated mortality. In epithelial carcinomas, a key process in metastatic progression is the epigenetic reprogramming of an epithelial-to-mesenchymal transition-like (EMT) change towards invasive cellular phenotypes. In non-epithelial cancers, different mechanisms must underlie metastatic change, but relatively little is known about the factors involved. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25923013
DOI: 10.1038/srep09841
PMCID: PMC4413894

Genes

SIRT7
SIRT1

Provenance

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